Uji Aktivitas Antiinflamasi Ekstrak Kulit Buah Langsat (Lansium domesticum Corr) Secara In Vivo

Abstract

The langsat plant (Lansium domesticum Corr) has long been utilized in herbal therapy in Indonesia. Langsat fruit peel extract contains secondary metabolites—such as flavonoids, tannins, alkaloids, and triterpenoids—that possess anti-inflammatory properties. This study aimed to evaluate the anti-inflammatory activity of langsat fruit peel extract and determine the most effective concentration for alleviating inflammation. A true experimental approach was employed using a pretest-posttest control group design. The experiment involved 25 male mice randomly assigned to five treatment groups: a positive control (2.5% hydrocortisone cream), a negative control (white petrolatum), and groups treated topically with langsat fruit peel extract at concentrations of 10%, 20%, and 40%. The research stages included extraction, phytochemical screening, preparation of test animals, and anti-inflammatory activity testing via 1% carrageenan induction. Data on the percentage of inflammation inhibition were statistically analyzed using the non-parametric Kruskal-Wallis test. The langsat fruit peel extract was found to contain flavonoids, triterpenoids, tannins, and alkaloids. The positive control group exhibited the highest level of inflammation inhibition; among the extract treatment groups, the 40% concentration showed the most optimal average inhibition percentage—approaching that of the positive control—followed by the 20% and 10% extracts. These findings indicate that higher extract concentrations yield more optimal anti-inflammatory effects; consequently, the results demonstrate that the 40% langsat fruit peel extract possesses the most optimal anti-inflammatory activity among the tested extract groups