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Abstract

Chronic kidney disease frequently leads to anemia, affecting up to 80–90% of patients, particularly those undergoing hemodialysis, as it contributes to reduced quality of life. In West Nusa Tenggara Province, the prevalence of chronic kidney disease accounts for 0.4% of national cases. This study aimed to analyze the effect of anti-anemia therapy on hemoglobin levels and quality of life in chronic kidney disease patients at NTB Provincial Hospital. The study used a prospective cross-sectional design based on hemodialysis patient medical records from 2025. Inclusion criteria included patients aged ≥18 years who had undergone routine hemodialysis for at least three months, received anti-anemia therapy, and had available hemoglobin laboratory results. Exclusion criteria were incomplete medical records or deteriorating clinical conditions. Subjects were divided into two groups: Erythropoietin monotherapy and a combination of Erythropoietin with iron/folic acid. Hemoglobin levels were measured before and after therapy using the Wilcoxon test, while quality of life was assessed using the validated SF-36 questionnaire and analyzed with the Mann-Whitney test. The results showed a significant increase in hemoglobin levels in both groups (p < 0.05), with a higher mean increase observed in the combination therapy group (2.2229 g/L). Additionally, the combination group demonstrated better quality of life scores, particularly in physical functioning, vitality, and social functioning. In conclusion, combination therapy with ESA and iron/folic acid is more effective in improving hemoglobin levels and enhancing the quality of life of chronic kidney disease patients undergoing hemodialysis.

Keywords

Anemia ESA Hemodialysis Quality of life SF-36

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Author Biographies

Baiq Indriswari, Program Studi Farmasi, Fakultas Kesehatan, Universitas Bumigora, Kota Mataram

Program Studi Farmasi, Fakultas Kesehatan, Universitas Bumigora, Kota Mataram

Fitri Apriliany, Program Studi Farmasi, Fakultas Kesehatan, Universitas Bumigora, Kota Mataram

Program Studi Farmasi, Fakultas Kesehatan, Universitas Bumigora, Kota Mataram

Novitarini Novitarini, Program Studi Farmasi, Fakultas Kesehatan, Universitas Bumigora, Kota Mataram

Program Studi Farmasi, Fakultas Kesehatan, Universitas Bumigora, Kota Mataram
How to Cite
Indriswari, B., Apriliany, F., & Novitarini, N. (2026). Analisis Pengaruh Pemberian Antianemia Pasien Gagal Ginjal Kronis Yang Menjalani Hemodialisa Di RSUD Provinsi NTB. Borneo Journal of Pharmascientech, 10(2), 248-259. https://doi.org/10.59053/bjp.v10i2.816
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