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Abstract

Cervical Cervical cancer is a global health problem that remains a major cause of death in women. The importance of developing alternative anticancer agents from safer natural ingredients. Begonia willemii is an endemic plant of Central Sulawesi which is reported to contain secondary metabolites that have the potential to be anticancer. This study aims to test the anticancer activity of ethanol extract of B. willemii against cervical cancer in female white rats (Rattus norvegicus) induced by DMBA (7,12-Dimethylbenz[a]anthracene) 20 mg/kgBW. B. willemii extract was obtained by maceration method using 96% ethanol. Twenty test animals were divided into 5 groups, namely normal control, positive control (cisplatin 5 mg/kgBW), and three treatment groups of B. willemii extract with doses of 100, 150, 200 mg/kgBW. Observations were made through Pap smear examination and histopathology of cervical tissue with Hematoxylin-Eosin staining. The results of the study showed that B. willemii extract has anticancer activity characterized by improvements in cervical tissue morphology and inhibition of abnormal epithelial cell proliferation, with an optimum dose of 100 mg/kgBW. Based on these findings, the ethanol extract of Begonia willemii has the potential as a candidate for a natural-based cervical anticancer agent.

Keywords

Anticancer Begonia willemii Cervical cancer DMBA

Article Details

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Author Biographies

Jamaluddin Jamal, Program Studi S1 Farmasi, Fakultas Farmasi dan Kesehatan Universitas Tjut Nyak Dhien, Medan

Program Studi S1 Farmasi, Fakultas Farmasi dan Kesehatan Universitas Tjut Nyak Dhien, Medan

I ketut Wahyu, Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako, Palu, Sulawesi Tengah

Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako, Palu, Sulawesi Tengah

Dewinda Purnama Sari, Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako, Palu, Sulawesi Tengah

Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako, Palu, Sulawesi Tengah

Diah Indri Astuti, Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako, Palu, Sulawesi Tengah

Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako, Palu, Sulawesi Tengah

Ni Luh Tissya Dewi, Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako, Palu, Sulawesi Tengah

Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako, Palu, Sulawesi Tengah

Amanda Naailah Maharani, Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako, Palu, Sulawesi Tengah

Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako, Palu, Sulawesi Tengah

Wahyu Purnawan, Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako, Palu, Sulawesi Tengah

Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako, Palu, Sulawesi Tengah

Recky Patala, Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako, Palu, Sulawesi Tengah

Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako, Palu, Sulawesi Tengah

Sri Sulistiana Sulaiman, Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako, Palu, Sulawesi Tengah

Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako, Palu, Sulawesi Tengah

Amelia Rumi, Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako, Palu, Sulawesi Tengah

Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako, Palu, Sulawesi Tengah
How to Cite
Jamal, J., Wahyu, I. ketut, Sari, D. P., Astuti, D. I., Dewi, N. L. T., Maharani, A. N., Purnawan, W., Patala, R., Pitriani, Sulaiman, S. S., & Rumi, A. (2026). Anticancer Activity of Ethanol Extract of Begonia willemii Endemic to Central Sulawesi In Vivo in Rat Model of Induced Cervical Cancer. Borneo Journal of Pharmascientech, 10(2), 225-235. https://doi.org/10.59053/bjp.v10i2.861
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