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Abstract

Type 2 diabetes mellitus is often accompanied by diabetic dyslipidemia, characterized by elevated triglyceride levels that increase the risk of cardiovascular complications. This study aimed to analyze the antihypertriglyceridemic effect of ethanolic extract of gegarang leaves (Mentha piperita L.) on triglyceride levels in alloxan-induced type 2 diabetic rats using various dose variations. This laboratory experimental study used a randomized controlled trial design involving 24 male white rats (Rattus norvegicus) randomly divided into six groups (n=4): a normal group, a negative control (alloxan), a positive control (alloxan + fenofibrate), and three treatment groups receiving extract doses of 75, 150, and 300 mg/kgBW. Diabetes was induced through a high-fat diet combined with alloxan 300 mg/kgBW, followed by oral administration of the ethanolic extract for 16 days. Triglyceride levels were measured spectrophotometrically before and after intervention and analyzed using One Way ANOVA and Post Hoc Tukey's HSD tests. The results showed that all treatment groups exhibited a decrease in triglyceride levels after intervention. It can be concluded that ethanolic extract of gegarang leaves (Mentha piperita L.) exhibits an antihypertriglyceridemic effect in alloxan-induced diabetic rats.

Keywords

Ethanolic extract Mentha piperita Triglyceride Alloxan-induced diabetes

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Author Biographies

Vivi Sofia, Program Studi S2 Biomedis, Fakultas Farmasi dan Kesehatan Universitas Tjut Nyak Dhien

Program Studi S2 Biomedis, Fakultas Farmasi dan Kesehatan Universitas Tjut Nyak Dhien

Tamara Luthfi Fissahari, Program Studi S1 Farmasi, Fakultas Farmasi dan Kesehatan Universitas Tjut Nyak Dhien

Program Studi S1 Farmasi, Fakultas Farmasi dan Kesehatan Universitas Tjut Nyak Dhien, Medan

Salmah Handayani Lubis, Program Studi S1 Farmasi, Fakultas Farmasi dan Kesehatan Universitas Tjut Nyak Dhien, Medan

Program Studi S1 Farmasi, Fakultas Farmasi dan Kesehatan Universitas Tjut Nyak Dhien, Medan
How to Cite
Sofia, V., Fissahari, T. L., & Lubis, S. H. (2026). The Antihypertriglyceridemic Effects of Ethanol Extract of Gegarang Leaves (Mentha piperita L.) in an Alloxan-Induced Diabetic Mouse Model. Borneo Journal of Pharmascientech, 10(2), 215-224. https://doi.org/10.59053/bjp.v10i2.864
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References

  1. Abdellatief, S. A., Beheiry, R. R., & El-Mandrawy, S. A. M. (2017). Peppermint essential oil alleviates hyperglycemia caused by streptozotocin- nicotinamide-induced type 2 diabetes in rats. Biomedicine & Pharmacotherapy, 95, 990–999. https://doi.org/10.1016/j.biopha.2017.09.020
  2. Aldoghachi, F. E. H., Noor Al-Mousawi, U. M., & Shari, F. H. (2021). Antioxidant Activity of Rosmarinic Acid Extracted and Purified from Mentha piperita. Archives of Razi Institute, (Online First). https://doi.org/10.22092/ari.2021.356072.1770
  3. Bellassoued, K., Ben Hsouna, A., Athmouni, K., Van Pelt, J., Makni Ayadi, F., Rebai, T., & Elfeki, A. (2018). Protective effects of Mentha piperita L. leaf essential oil against CCl4 induced hepatic oxidative damage and renal failure in rats. Lipids in Health and Disease, 17(1), 9. https://doi.org/10.1186/s12944-017-0645-9
  4. Cao, S., Liu, M., Han, Y., Li, S., Zhu, X., Li, D., Shi, Y., & Liu, B. (2024). Effects of Saponins on Lipid Metabolism: The Gut–Liver Axis Plays a Key Role. Nutrients, 16(10), 1514. https://doi.org/10.3390/nu16101514
  5. Datu, O. S., Lebang, J. S., & Rumondor, E. M. (2021). Pengaruh Pemberian Sari Buah Salak (Salacca zalacca) terhadap Profil lipid dan Berat Badan Tikus Model Hiperlipidemia dan Obesitasda. Jurnal MIPA, 11(1). https://doi.org/10.35799/jm.v11i1.36530
  6. Fakhira, D. E. (2022). STUDI LITERATUR AKTIVITAS ANTIDIABETES TANAMAN SUKU CUCURBITACEAE. Jurnal Ilmiah Farmasi Farmasyifa, 5(2), 140–151. https://doi.org/10.29313/jiff.v5i2.9547.
  7. GBD 2021 Diabetes Collaborators. (2023). Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: A systematic analysis for the Global Burden of Disease Study 2021. The Lancet, 402, 203–234. https://doi.org/10.1016/S0140-6736(23)01301-6
  8. Kemenkes RI (2017). Farmakope Herbal Indonesia Edisi II.
  9. Ighodaro, O. M. (2018). Molecular pathways associated with oxidative stress in diabetes mellitus. Biomedicine & Pharmacotherapy, 108, 656–662. https://doi.org/10.1016/j.biopha.2018.09.058
  10. Ignasius Agyo Palmado, Sulistyanaengci Winarto, Honey Dzikri Marhaeny, Yusuf Alif Pratama, Chrismawan Ardianto, & Khotib, J. (2024). The Effect of Quercetin on Coenzyme HMG-CoAR, ABCA1 Transporter, Dyslipidemia Profile and Hepatic Function in Rats Dyslipidemia Model. JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA, 11(3), 274–290. https://doi.org/10.20473/jfiki.v11i32024.274-290
  11. Kersten, S. (2023). The impact of fasting on adipose tissue metabolism. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1868(3), 159262. https://doi.org/10.1016/j.bbalip.2022.159262
  12. Khutami, C., Sumiwi, S. A., Khairul Ikram, N. K., & Muchtaridi, M. (2022). The Effects of Antioxidants from Natural Products on Obesity, Dyslipidemia, Diabetes and Their Molecular Signaling Mechanism. International Journal of Molecular Sciences, 23(4), 2056. https://doi.org/10.3390/ijms23042056
  13. Lanez, E., Bekkar, Y., Bourougaa, L., Benamor, M. L., Bouraoui, R., Boudebia, O., Adaika, A., Nesba, K., Chaoua, H., Bechki, L., Lanez, T., Alsaeedi, H., Bechelany, M., & Barhoum, A. (2026). Antidiabetic potential of Mentha piperita essential oil: GC–MS profiling, in vitro, in vivo and in silico analyses. Journal of Molecular Structure, 1351, 144239. https://doi.org/10.1016/j.molstruc.2025.144239
  14. Li, Y., Liu, Y., Ma, A., Bao, Y., Wang, M., & Sun, Z. (2017). In vitro antiviral, anti-inflammatory, and antioxidant activities of the ethanol extract of Mentha piperita L. Food Science and Biotechnology, 26(6), 1675–1683. https://doi.org/10.1007/s10068-017-0217-9
  15. Maryuni, D. R., Prameswari, D. A., Astari, S. D., Sari, S. P., & Putri, D. N. (2022). Identification of active compounds in red onion (Allium ascalonicum) peel extract by LC-ESI-QTOF-MS/MS and determination of its antioxidant activity. Jurnal Teknologi Hasil Pertanian, 15(1), 20. https://doi.org/10.20961/jthp.v15i1.55451
  16. Mohammed, H. A., Sallau, A. B., Nzelibe, H. C., Muhammad, A., Erukainure, O. L., Musa, B., & Anigo, M. K. (2021). Bioactive Fraction of Mentha piperita Leaves Extract Stimulates Lipoprotein Lipase at Cellular and Molecular Levels via Augmentation of Antioxidant Defense System in Hyperlipidemic Rats. Journal of Herbs, Spices and Medicinal Plants, 27(3), 267–288. https://doi.org/10.1080/10496475.2021.1891176
  17. Mutha, R. E., Tatiya, A. U., & Surana, S. J. (2021). Flavonoids as natural phenolic compounds and their role in therapeutics: An overview. Future Journal of Pharmaceutical Sciences, 7(1), 25. https://doi.org/10.1186/s43094-020-00161-8
  18. Putri, T. A., Ruyani, A., & Nugraheni, E. (2017). Uji efek pemberian ekstrak metanol daun beluntas (Pluchea indica L.) terhadap kadar glukosa dan trigliserida darah mencit (Mus musculus) yang diinduksi sukrosa. Jurnal Kedokteran Raflesia, 3(1), 93–106..
  19. Sofia, Vivi (2025). "Sindrom metabolik dan Dislipidemia." Penamuda Media.
  20. Sofia, V., Firdaus, T. N., & Saputri, M. (2024). Phytochemical Screening and Anti-hyperglycemic Effect Test of Ethanol Extract of Waru Leaf (Hibiscus tiliaceus) on Glucose-loaded Mice. JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA, 11(3), 345–355. https://doi.org/10.20473/jfiki.v11i32024.345-355
  21. Vivi, S., Atiya, R., & Muflihah, F. (2026). Phytochemical screening of ethanolic extract of Kopasanda (Chromolaena odorata (L) RM King and H Rob) leaves and its anti-hyperglycaemic activity in the mouse model of hyperglycaemia. Scripta Medica, 57(1), 15–25. https://doi.org/10.5937/scriptamed57-58804