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Abstract

Acne is a skin disease caused by pathogenic bacteria such as Propionibacterium acne and Staphylococcus aureus. Pegagan leaves (Centella asiatica) are a natural ingredient that has antibacterial properties. This ingredient was combined with niacinamide as an antioxidant in a peel-off gel mask preparation to make it easier to use. This study aimed to determine the best peel-off gel mask formula for pegagan leaf extract and niacinamide based on the evaluation of characteristics and stability and antibacterial, antioxidant, and irritant effects on the skin. In this study, we used experimental methods. Pegagan leaf extract was varied in concentrations of 1.25%, 2.5%, and 5%. In the characteristic test, which included organoleptic tests, viscosity, spreadability, drying time, and pH value, we obtained the preparation results with good characteristics. The preparation has good physical stability but is not chemically stable, and it was tested using the freeze-thaw method. The results of the antioxidant test of the preparations in the three formulas showed weak antioxidant activity, with IC50 values ​​of F1 228.54ppm, F2 147.22ppm, and F3 120.35ppm. The results of the antibacterial test showed that the preparations had more potential for Propionibacterium acne bacteria, with results of F1 15.43±1.52mm, F2 15.57±0.82mm, and F3 17.37±0.34mm. The three formulas found no irritation effects using the HET-CAM method. Based on the results of this study, the peel-off gel mask of pegagan leaf extract combined with niacinamide has the potential as an anti-acne preparation.

Keywords

Peel-off Mask Gel Pegagan Leaf Extract Niacinamide Antibacterial Antioxidant Irritability

Article Details

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Author Biographies

Uswatun Chasanah, Muhammadiyah Malang University

Program Studi Farmasi, Fakultas Ilmu Kesehatan, Universitas Muhammadiyah Malang

Dyah Rahmasari, Universitas Muhammadiyah Malang

Program Studi Farmasi, Fakultas Ilmu Kesehatan, Universitas Muhammadiyah Malang

Cynthia Ayu Desinta, Muhammadiyah Malang University

Program Studi Farmasi, Fakultas Ilmu Kesehatan, Universitas Muhammadiyah Malang

Fella Febriana, Muhammadiyah Malang University

Program Studi Farmasi, Fakultas Ilmu Kesehatan, Universitas Muhammadiyah Malang

Hera Nadila Pertiwi, Muhammadiyah Malang University

Program Studi Farmasi, Fakultas Ilmu Kesehatan, Universitas Muhammadiyah Malang

Nanda Trisna Olivia, Muhammadiyah Malang University

Program Studi Farmasi, Fakultas Ilmu Kesehatan, Universitas Muhammadiyah Malang
How to Cite
Chasanah, U., Rahmasari, D., Desinta, C. A., Febriana, F., Pertiwi, H. N., & Olivia, N. T. (2026). Masker Gel Peel-off Kombinasi Ekstrak Daun Pegagan (Centella asiatica) dan Niacinamide: Formulasi, Efektivitas Antibakteri, Aktivitas Antioksidan, dan Iritabilitas. Borneo Journal of Pharmascientech, 10(1), 309-323. https://doi.org/10.59053/bjp.v10i1.628
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References

  1. Akmal, T., P. Tanjung, Y., & P. Nurlaela, S. (2022). Formulation of Peel-off Gel Face Mask from Pandanus amaryllifolius (Roxb.) Leaves Extract. Indonesian Journal of Pharmaceutical Science and Technology, 1(1), 96. https://doi.org/10.24198/ijpst.v1i1.43015
  2. Asmiati, E., Rahmasari, D., Winata, D. A., Prinastiti, I. N., Kartika Sari, M., Indah, R. A., & Nugraheni, R. W. (2022). Formulation of Peel-Off Masks Containing Duwet Leaf Extract (Syzygium Cumini). KnE Medicine, 2022, 350–371. https://doi.org/10.18502/kme.v2i3.11886
  3. Batista-Duharte, A., Murillo, G. J., Pérez, U. M., Tur, E. N., Portuondo, D. F., Martínez, B. T., Téllez-Martínez, D., Betancourt, J. E., & Pérez, O. (2016). The Hen’s Egg Test on Chorioallantoic Membrane: An Alternative Assay for the Assessment of the Irritating Effect of Vaccine Adjuvants. International Journal of Toxicology, 35(6), 627–633. https://doi.org/10.1177/1091581816672187
  4. Chasanah, U., Nurwiyanti, A., Salsabilla Miftakhurrohmah, A., Hamid Afif, M., Najihah, Z., Rizky Hanwidi Putra, R., & Rahmasari, D. (2023). Optimation of Emulgel Combination of Tea Tree Oil and Lavender Oil: Evaluation and Antibacterial Study. KnE Medicine, 2023, 518–529. https://doi.org/10.18502/kme.v3i2.13087
  5. Do, Q. D., Angkawijaya, A. E., Tran-Nguyen, P. L., Huynh, L. H., Soetaredjo, F. E., Ismadji, S., & Ju, Y. H. (2014). Effect of extraction solvent on total phenol content, total flavonoid content, and antioxidant activity of Limnophila aromatica. Journal of Food and Drug Analysis, 22(3), 296–302. https://doi.org/10.1016/j.jfda.2013.11.001
  6. Fitriyani, P., Sujono, H., Aisyah, L. S., Kesuma, D., Siswandono, S., Purwanto, B. T., Hardjono, S., Raies, A. B., Bajic, V. B., Aktivitas, P., Sofyan, A. N., Zhao, T., Ding, K. M., Zhang, L., Cheng, X. M., Wang, C. H., & Wang, Z. T. (2013). Uji Aktivitas Antimikroba Minyak Atsiri Tanaman Pegagan ( Centella asiatica ( L .) Urb ) Antimicrobial Activity Test of Essential Oil from Pegagan Plant ( Centella asiatica ( L .) Urb ). Wiley Interdisciplinary Reviews: Computational Molecular Science, 2013(1), 147–172.
  7. Gani, A., Nazar, M., & Restiana, D. L. (2024). Peel-Off Mask Formulation for Facial Skin Protection Made from Active Carbon Quantum Dots From Rice Washing Water. Al Kimiya, 11(1), 84–94. https://doi.org/10.15575/ak.v11i1.36475
  8. Hapsari, R. P., Widayati, R. I., Afriliana, L., & Hadi, P. (2020). the Efficacy of Topical Clindamycin Gel on Severity Degree of Acne Vulgaris Among Female College Students. Diponegoro Medical Journal , 9(4), 380–384. http://ejournal3.undip.ac.id/index.php/medico
  9. Huang, Y., Li, S., Pan, J., Song, C., Chen, W., & Zhang, Y. (2024). Liquiritin Carbomer Gel Cold Paste Promotes Healing of Solar Dermatitis in Mice. International Journal of Molecular Sciences, 25(7). https://doi.org/10.3390/ijms25073767
  10. Khaira, Z., Monica, E., & Yoedistira, C. D. (2022). FORMULASI DAN UJI MUTU FISIK SEDIAAN SERUM MIKROEMULSI EKSTRAK BIJI MELINJO Gnteum gnemon L. Sainsbertek Jurnal Ilmiah Sains & Teknologi, 3(1), 299–309. https://doi.org/10.33479/sb.v3i1.197
  11. Kolhe, P., Amend, E., & Singh, S. K. (2010). Impact of freezing on pH of buffered solutions and consequences for monoclonal antibody aggregation. Biotechnology Progress, 26(3), 727–733. https://doi.org/10.1002/btpr.377
  12. Lestari, I., Lestari, U., & Gusti, D. R. (2018). Antioxidant activity and irritation test of peel off gel mask of ethanol extract of pedada fruit ( Sonneratia caseolaris ). INTERNATIONAL CONFERENCE ON PHARMACEUTICAL RESEARCH AND PRACTICE, 978–979.
  13. Luthfiyana, N., Nurhikma, N., & Hidayat, T. (2019). Characteristics of Peel Off Gel Mask From Seaweed (Eucheuma cottonii) Porridge. Jurnal Pengolahan Hasil Perikanan Indonesia, 22(1), 119. https://doi.org/10.17844/jphpi.v22i1.25888
  14. Marques, C., Hadjab, F., Porcello, A., Lourenço, K., Scaletta, C., Abdel-Sayed, P., Hirt-Burri, N., Applegate, L. A., & Laurent, A. (2024). Mechanistic Insights into the Multiple Functions of Niacinamide: Therapeutic Implications and Cosmeceutical Applications in Functional Skincare Products. Antioxidants, 13(4), 1–18. https://doi.org/10.3390/antiox13040425
  15. Naibaho, O. H., Yamlean, P. V. Y., & Wiyono, W. (2013). Pengaruh Basis Salep Terhadap Formulasi Sediaan Salep Ekstrak Daun Kemangi (Ocimum sanctum L.) Pada Kulit Punggung Kelinci yang Dibuat Infeksi Staphylococcus aureus. Jurnal Ilmiah Farmasi-UNSRAT, 2(02), 27–34.
  16. Park, H. J., Byun, K. A., Oh, S., Kim, H. M., Chung, M. S., Son, K. H., & Byun, K. (2022). The Combination of Niacinamide, Vitamin C, and PDRN Mitigates Melanogenesis by Modulating Nicotinamide Nucleotide Transhydrogenase. Molecules, 27(15), 1–17. https://doi.org/10.3390/molecules27154923
  17. Pratiwi, L., & Wahdaningsih, S. (2018). FORMULASI DAN AKTIVITAS ANTIOKSIDAN MASKER WAJAH GEL PEEL OFF EKSTRAK METANOL BUAH PEPAYA (Carica papaya L.). Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ), 1(2), 50–62. https://doi.org/10.35799/pmj.1.2.2018.21643
  18. Puspita, W., & Puspasari, H. (2022). Physical Stability and Antioxidant Activity of Peel-Off Gel Mask Ethanol Extract of Buas-buas Leaf (Premna serratifolia L.). Majalah Obat Tradisional, 27(2), 93–99. https://doi.org/10.22146/mot.71033
  19. Putri, M., Capritasari, R., Wijayatri, R., & Ardian, Y. (2024). FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN SEDIAAN MASKER GEL PEEL OFF EKSTRAK ETANOL DAUN PEGAGAN ( Centella asiatica ( L .) Urban ). 08(02), 194–206.
  20. Rahmasari, D., Juwanti, A., Pratiwi, I., Diana, N. Z., Nugraheni, R. W., & Rakhma, D. N. (2021). Antioxidant and UV Protection Activities of Squid (Loligo sp.) Ink Powder Lotions. Borneo Journal of Pharmacy, 4(1), 22–28. https://doi.org/10.33084/bjop.v4i1.1675
  21. Ratz-Lyko, A., Arct, J., & Pytkowska, K. (2016). Moisturizing and antiinflammatory properties of cosmetic formulations containing Centella asiatica extract. Indian Journal of Pharmaceutical Sciences, 78(1), 27–33. https://doi.org/10.4103/0250-474X.180247
  22. Reviana, R., Usman, A. N., Raya, I., Aliyah, Dirpan, A., Arsyad, A., & Fendi, F. (2021). Analysis of antioxidant activity on cocktail honey products as female pre-conception supplements. Gaceta Sanitaria, 35(2014), S202–S205. https://doi.org/10.1016/j.gaceta.2021.10.021
  23. Salmannejad, F., Qorab, H., & Ghari, T. (2024). Formulation, Characterization and Optimization of Peel-Off Gel of Soybean Extract as a Face Mask. Tropical Journal of Natural Product Research, 8(3), 6544–6551. https://doi.org/10.26538/tjnpr/v8i3.11
  24. Sari, D. Y., & Rahman, I. R. (2021). Keamanan Hair Tonic Ekstrak Etanol, Fraksi Etanol, dan Fraksi Kloroform-Metanol dari Kayu Secang (Caesalpinia sappan L.) dengan Metode Uji Iritasi Primer dan HET-CAM. Jurnal Farmasi Udayana, 10(2), 156. https://doi.org/10.24843/jfu.2021.v10.i02.p08
  25. Sieberi, B. M., Omwenga, G. I., Wambua, R. K., Samoei, J. C., & Ngugi, M. P. (2020). Screening of the Dichloromethane: Methanolic Extract of Centella asiatica for Antibacterial Activities against Salmonella typhi, Escherichia coli, Shigella sonnei, Bacillus subtilis, and Staphylococcus aureus. Scientific World Journal, 2020. https://doi.org/10.1155/2020/6378712
  26. Sigalingging, O. S., & Musfiroh, I. (2022). Analisis Kualifikasi Pemasok Obat di Salah Satu Pedagang Besar Farmasi (PBF) di Kota Bandung. Majalah Farmasetika, 7(5), 469–477.
  27. Sopianti, D. S., & Agustin, M. (2019). Masker Gel Peel Off Dari Ekstrak Wortel (Daucus carota L). Borneo Journal of Phamascientech, 03(02), 110–118. http://jurnalstikesborneolestari.ac.id/index.php/borneo/article/view/245
  28. Susanti, R. E. E., & Ayun, Q. (2022). Formulation and Antioxidant Activity of Peel Off Gel Mask from Paederia Foetida Extract. JKPK (Jurnal Kimia Dan Pendidikan Kimia), 7(1), 12. https://doi.org/10.20961/jkpk.v7i1.45798
  29. Titin Agustiningsih, Tuhfatul Ulya, Evi Fatmi Utami, Hardani, & Sri Idawati. (2024). Formulasi Ekstrak Daun Pegagan (Centella Asiatica) Dan Ekstrak Daun Kelor (Moringa Oleifera) Sebagai Masker Gel Peel-Off. Pharmaceutical and Traditional Medicine, 8(1), 24–35. https://doi.org/10.33651/ptm.v8i1.666
  30. Tri Wahyuni, S., Rahmasari, D., Sandi Nugroho, R., Agusta, I., Dithya Kurnia Daminda, R., Vikri Sundugesti, R., & Ermawati, D. (2023). Enhanced Antibacterial Activity of Piper betle Extract Niosome Serum Gel and Its Irritation Effects. KnE Medicine, 2023, 178–188. https://doi.org/10.18502/kme.v3i2.13050
  31. Utari, F. D., Hilaliyati, N., & Afriani, T. (2024). Evaluation and Antibacterial Activity Test of Peel-off Mask Preparation from Combination of Pegagan Leaves (Centella asiatica (L) Urb.) and Charcoal Powder. Biology, Medicine, & Natural Product Chemistry, 13(1), 127–133. https://doi.org/10.14421/biomedich.2024.131.127-133
  32. Vieira, R. P., Fernandes, A. R., Kaneko, T. M., Consiglieri, V. O., Pinto, C. A. S. D. O., Pereira, C. S. C., Baby, A. R., & Velasco, M. V. R. (2009). Physical and physicochemical stability evaluation of cosmetic formulations containing soybean extract fermented by Bifidobacterium animalis. Brazilian Journal of Pharmaceutical Sciences, 45(3), 515–525. https://doi.org/10.1590/S1984-82502009000300018
  33. Wahdaningsih, S., Rizkifani, S., & Utari, E. K. (2023). Anti-Aging Peel-Off Mask of Dragon Fruit Peel Extract (Hylocereus Polyrhizus). Jurnal Farmasi Sains Dan Praktis, 9(3), Pdf. https://doi.org/10.31603/pharmacy.v9i3.8837
  34. Ye, T., Chen, X., Zhu, Y., Chen, Z., Wang, Y., Lin, L., Zheng, Z., & Lu, J. (2022). Freeze-Thawing Treatment as a Simple Way to Tune the Gel Property and Digestibility of Minced Meat from Red Swamp Crayfish (Procambarus clarkiix). Foods, 11(6). https://doi.org/10.3390/foods11060837