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Abstract

Oil palm (Elaeis guineensis) leaves possess diverse pharmacological properties with promising development potential, particularly as antibiofilm and antioxidant agents. This study aimed to evaluate the antibacterial, antibiofilm, and antioxidant activities of E. guineensis leaf extract. The leaves were macerated in acetone for five days. Antibacterial activity was determined using the disc diffusion method against four bacterial species: Staphylococcus aureus, Propionibacterium acnes, Escherichia coli, and Pseudomonas aeruginosa. The extract exhibited moderate antibacterial activity, with the highest inhibition observed against P. acnes (6.79 mm at 25%). Antibiofilm activity was evaluated using a microdilution method, showing concentration-dependent inhibition, with the highest activity at 1% concentration, reaching 83.90% (mid-phase, S. aureus) and 71.28% (E. coli). Antioxidant activity was assessed using DPPH, FRAP, and ABTS assays, yielding IC50 values of 99.19 ppm, 119.12 ppm, and 123.37 ppm, respectively, indicating moderate antioxidant capacity (IC50 > 50-150 ppm). Overall, E. guineensis leaf extract demonstrates moderate antibacterial, antibiofilm, and antioxidant activities, suggesting its potential as a preliminary candidate for further pharmacological investigation.

Keywords

E. Guineensis Antioxidant Antibiofilm Antibacterial

Article Details

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Author Biographies

Deni Setiawan, Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Lambung Mangkurat University, Banjarbaru, South Kalimantan, Indonesia.

Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Lambung Mangkurat University, Banjarbaru, South Kalimantan, Indonesia.

Samsul Hadi, Departement of Pharmacy, Faculty of Mathematics and Natural Sciences, Lambung Mangkurat University, Banjarbaru, South Kalimantan, Indonesia.

Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Lambung Mangkurat University, Banjarbaru, South Kalimantan, Indonesia.

Nur Mahdi, Departement of Pharmacy, Faculty of Mathematics and Natural Sciences, Lambung Mangkurat University, Banjarbaru, South Kalimantan, Indonesia.

Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Lambung Mangkurat University, Banjarbaru, South Kalimantan, Indonesia.

Nurul Mardiati, Departement of Pharmacy, Faculty of Mathematics and Natural Sciences, Lambung Mangkurat University, Banjarbaru, South Kalimantan, Indonesia.

Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Lambung Mangkurat University, Banjarbaru, South Kalimantan, Indonesia.

Dita Ayulia Dwi Sandi, Departement of Pharmacy, Faculty of Mathematics and Natural Sciences, Lambung Mangkurat University, Banjarbaru, South Kalimantan, Indonesia.

Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Lambung Mangkurat University, Banjarbaru, South Kalimantan, Indonesia.

Muhammad Rasyid Ridha, Department of Public Health, Faculty of Medicin, Lambung Mangkurat University, Banjarbaru, South Kalimantan, Indonesia

Department of Public Health, Faculty of Medicin, Lambung Mangkurat University, Banjarbaru, South Kalimantan, Indonesia

Moch. Saiful Bachri, Department of Pharmacy, Faculty of Pharmacy, Ahmad Dahlan University, Yogyakarta, Indonesia.

Department of Pharmacy, Faculty of Pharmacy, Ahmad Dahlan University, Yogyakarta, Indonesia.
How to Cite
Setiawan, D., Hadi, S., Mahdi, N., Mardiati, N., Dwi Sandi, D. A., Ridha, M. R., & Bachri, M. S. (2026). Biomedicine Potential of Oil Palm (Elaeis guineensis) Leaves: In Vitro Evaluation of Antibacterial, Antibiofilm, and Antioxidant Activities . Borneo Journal of Pharmascientech, 10(1), 462-470. https://doi.org/10.59053/bjp.v10i1.794
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